KETAMINE FACT SHEET FUNDAMENTALS EXPLAINED

Metabolism Ketamine is metabolized by using N-dealkylation towards the Lively metabolite norketamine generally by CYP2B6 and CYP3A4 and also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation from the cyclohexone ring to form hydroxynorketamine compounds by way of CYP-dependent pathways, which are conjugated with glucuroni